The Journal of Phytopharmacology, 2015;4(3):133-138 DOI:10.31254/phyto.2015.4301
Pharmacognostical, phyotochemical and toxicity profile of flower of Ishwari - Aristolochia indica Linn
Mohammed Faisal1 , Bairy Sridhar2 , KN Sunil Kumar3 , Sudhakara4 , Ravi M4
1. Assistant Professor, Department of Dravyaguna, SDM College of Ayurveda, Kuthpady, Udupi, Karnataka-574118, India
2. Professor and HOD, Department of PG studies in Dravyaguna, SDM College of Ayurveda, Kuthpady, Udupi, Karnataka-574118, India
3. Senior Research Officer, Department of Pharmacognosy, SDM College of Ayurveda, Kuthpady, Udupi, Karnataka574118, India
4. Research Officer, Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi-574 118, India
*Author to whom correspondence should be addressed.
Aristolochia indica Linn. (Aristolochiaceae) is popularly known as Ishwari and Nakuli in Samhitha Granthas. Ishwari is used in different forms for condition like sheethajwara, sarpavisha, vrana, ekangashopha, unmada, apasmara etc. One of methods of plant wealth conservation is by promoting use of plant parts other than root in therapeutics. Flower is one such plant part which can be studied as substitute for therapeutic benefits of root. Prior to such trials such proposed substitutes must undergo various pharmacognostical, analytical, toxicological and pharmacological studies. Microscopy, phtochemical examination, HPTLC and acute toxicity studies of A. indica flowers were performed flowing standard procedure. Powder microscopy revealed some specific characters for its identification. Phytochemical study showed presence of steroid, carbohydrate, flavonoids and saponins. HPTLC fingerprint of the flowers was derived. On toxicity evaluation no adverse effects were observed on administration of powder of flower orally in rat. These diagnostic features can be used as a fingerprint for the identification and differentiation of their substitute and adulterants of the plant. As there is no toxicity up to 2000 mg/kg body weight, 1/10 of the dose i.e. 200 mg/kg can be considered as therapeutic dose for further studies on this drug.
Microscopy, Phytochemical, HPTLC, OECD, Substitution
HOW TO CITE THIS ARTICLE
Faisal M, Shridhar B, Kumar SK, Ravi SM. Pharmacognostical phytochemical and toxicity profile of flower of Ishwari: Aristolochia indica Linn. J Phytopharmacol. 2015;4(3):133-8.
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