The Journal of Phytopharmacology, 2021;10(5):282-285 DOI:10.31254/phyto.2021.10501

Research Article

Evaluation of acute oral toxicity of herbal rumenotoric and stomachic

Sunil Hajare¹ , Ranjit Suresh Ingole¹ , Maheshkumar Vitthal Ingawale¹ , Vivek Borekar² , Ravikanth Kotagiri³ , Bhaskar Ganguly⁴

Sunil Hajare,Ranjit Suresh Ingole,Maheshkumar Vitthal Ingawale,Vivek Borekar,Ravikanth Kotagiri,Bhaskar Ganguly

1. Post Graduate Institute of Veterinary and Animal Sciences (PGIVAS), Akola - 444104 Maharashtra, India
2. Post Graduate Institute of Veterinary and Animal Sciences (PGIVAS), Akola, - 444104 Maharashtra, India
3. Research and Development Unit, Ayurvet Limited, Baddi - 173205 Maharashtra, India
4. Research and Development Unit, Ayurvet Limited, Baddi – 173205 Maharashtra, India

*Author to whom correspondence should be addressed.

Received: 5th August, 2021 / Accepted: 20th August, 2021

Abstract

Maintaining optimum digestive functions is crucial for achieving health and profitability in livestock enterprises. However, the efficiency of these functions is upset by common problems such as indigestion, anorexia, flatulence, ruminal stasis and impaction. Pachoplus™ (M/s Ayurvet Limited, India) is a polyherbal rumenotoric, carminative and stomachic that helps to achieve and restore optimum digestive functions in livestock. A study was undertaken to evaluate the potential of Pachoplus™ to elicit acute oral toxicity as per OECD 423 guidelines. Nine non-pregnant, nulliparous, adult female Swiss albino mice were used for the study. The animals were observed for the manifestation of toxic effects and mortality after the oral administration of the test substance. Toxicity was evaluated on the basis of changes in body weight, overt signs of toxicity, gross and histological appearances of vital organs, and blood biochemistry. Pachoplus™ was found safe for oral use as no toxic effects or mortalities were observed till day 14.