The Journal of Phytopharmacology, 2020;9(4):230-235 ; DOI:10.31254/phyto.2020.9403
Antidiabetic property of Chrysophyllum albidum extract in Streptozotozin- induced diabetic rats
Olufunke Christy Akanji1 , Benjamin Ogunma Gabriel2 , Emmanuel Ola Oshomoh3 , Osagie Steve Asuelimen4
1. Department of Plant Science and Biotechnology, Adekunle Ajasin University, Akungba Akoko, Ondo State. Nigeria
2. Phytomedicine Unit, Faculty of Life Sciences, University of Benin, PMB 1154, Benin City, Edo State
3. Department of Science Laboratory Technology, Faculty of Life Sciences, University of Benin, Edo State. Nigeria
4. Department of Biochemistry, Federal University, Wukari, Taraba State. Nigeria
*Author to whom correspondence should be addressed.
Received: 22nd May, 2020 / Accepted: 9th June, 2020
This study is aimed at evaluating the anti-diabetes property of Chrysophyllum albidum on Streptozotozininduced Diabetic mellitus in rats. Diabetic mellitus induced intraperitoneally with streptozotocin (STZ) using standard dose of 40 mg/kg after fasted for 12 hours as protocol implies. Blood glucose levels were determined using Accu-check glucometer before and during treatment of 10 and 30 mg/kg C. albidum when compared with Metformin and diabetic control groups. Animals whose blood glucose level was above 200 mg/dL were considered diabetic. After 28 days of treatment, blood and tissue samples were isolated for fasting blood sugar, haematological, bioassay and histopathological study using standard procedures. Result revealed a significant decrease (p0.05) now some parameters across treated groups excluding 10 mg/kg of C. albidum of MCH that showed a significant difference when compared with metformin and control group. Result showed a significant increase in the level of CAT, SOD, MDA and GST across the treated groups (10 and 30 mg/kg C. albidum) ethanol extract when compared with standard (10 mg/kg metformin) and diabetic control. The histopathological alteration observed in this study include; severe interlobular oedema and fatty droplets in the interlobular ducts and connective tissues. These alterations were prominent in the diabetic control group while 30 mg/kg of C. albidum showed prominent reduction in damage done by an anti-diabetonic agent (streptozotocin). This study showed that C. albidum is effective in the management of diabetes, which concord with its ethnomedicinal reports.
Chrysophyllum albidum, Diabetes mellitus, Streptozotocin, Metformin.
HOW TO CITE THIS ARTICLE
Akanji OC, Gabriel BO, Oshomoh EO, Asuelimen OS. Antidiabetic property of Chrysophyllum albidumextract in Streptozotozin- induced Diabetic Rats. J Phytopharmacol 2020; 9(4):230-235.
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