The Journal of Phytopharmacology, 2019;8(3):96-103 ; DOI:10.31254/phyto.2019.8303
Anti-inflammatory potential of Tapinanthus globiferus (Loranthaceae) leaves as an alternative treatment against arthritis
Gounoue Kamkumo Raceline1,2 , Noukeu Kamta Bruno Aubin1,3 , Tsakem Nangap Marius Jaures1,4 , Youmsi Fokouo Ducos4 , Ngueguim Tsofack Florence1 , Dzeufiet Djomeni Paul Desire1 , Dimo Théophile1 , Penlap Beng Véronique3
1. Laboratory of Animal Physiology, Department of Animal Biology and Physiology, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon
2. Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon 3) Centre for Research on Filariasis and Other Tropical Diseases, P.O.Box 5797 Yaoundé, Cameroon
3. Laboratory for tuberculosis research and pharmacology, Department of Biochemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon
4. Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon
*Author to whom correspondence should be addressed.
Received: 10th April, 2019 / Accepted: 25th May, 2019
Rheumatoid arthritis is a systemic autoimmune inflammatory disease which treatment remains a challenge, due to adverse effects caused by conventional medicines. The study assesses the effects of aqueous extract of Tapinanthus globiferus leaves on complete Freund’s adjuvant (CFA)-induced rheumatoid arthritis in rat. Rheumatoid arthritis was induced by inoculation of 0.1 mL of CFA under the plantar aponeurosis of rat. Animals were daily treated for 10 days with distilled water (10 mL/kg), sodium diclofenac (5 mg/kg) and aqueous extract of T. globiferus at doses of 50, 100 and 200 mg/kg. Healthy animals received distilled water (10 mL/kg). The volume of edema of the hind paw was measured using a plethysmometer. At the end of the treatment the animals were sacrificed, blood was collected for hematological and biochemical analyses. Some organs such as liver, kidney and tibiotarsal joint were used for biochemical and histological analyses. The administration of the aqueous extract of T. globiferus to diseased rats significantly alleviated physiological impairement by reducing of paw volume (p < 0.001), protecting animals from anemia (p < 0.001), leukocytosis (p < 0.001), transaminases activity increasing (p < 0.001), alkaline phosphatase (p < 0.01) and hypercreatininemia (p < 0.001). The plant extract has improved the antioxidant status of animals (p < 0.001) and the architectural organisation at joint level. The beneficial effects generated by the aqueous extract of T. globiferus leaves against the physiological dysfunctions caused by CFA justify its current use in the traditional treatment of rheumatoid arthritis.
Rheumatoid arthritis, complete Freund's adjuvant, Tapinanthus globiferus, curative activity, acute toxicity.
HOW TO CITE THIS ARTICLE
Raceline GK, Aubin NKB, Jaures TNM, Ducos YF, Florence NT, Desire DDP, et al. Anti -inflammatory potential of Tapinanthus globiferus (Loranthaceae) leaves as an alternative treatment against arthritis . J Phytopharmacol 201 9 ; 8 ( 3):96 -103 .
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