The Journal of Phytopharmacology, 2019;8(5):216-219 ; DOI:10.31254/phyto.2019.8502
Study of antianemic properties of Parquetina nigrescens (Apocynaceae) in wistar rats
Gui Prisca Angèle1 , Bahi Calixte1 , Kamou Kamou Richard1 , Tiekpa Wawa Justine2 , Gnaléi Rabé Marcellin3 , Djyh Nazaire1 , Coulibaly Adama1
1. Biochemical Pharmacodynamy Laboratory, Biosciences Department, Felix Houphouët-Boigny University of Cocody, PO Box 582 Abidjan 22, Côte d’Ivoire
2. Laboratory of Biotechnology and Valorization of Agroresources, UFR Biological Sciences, Peleforo Gon Coulibaly University, Korhogo, BP 1328 Korhogo, Ivory Coast
3. Biochemical Pharmacodynamy Laboratory Biosciences Department, Felix Houphouët-Boigny University of Cocody, PO Box 582 Abidjan 22, Côte d’Ivoire
*Author to whom correspondence should be addressed.
Received: 24th August, 2019 / Accepted: 11th October, 2019
Stability Parquetina nigrescens is a plant of the family Apocynaceae. She is commonly called "baba niama" in Boulé, and she is used in Côte d'Ivoire in the treatment of anemia in a traditional environment. Our study aims to know the different chemical components of the plant and test the antianemic properties of the total aqueous Extract on Wistar rats, after induction of anemia by phenylhydrazine hydrochloride. Phytochemical analysis revealed the presence of alkaloids, tannins, flavonoids, polyphenols, and polyterpenes and iron. The administration of the aqueous extract by gavage to the anemic rats at doses of 2000 mg/kg/day and 2500 mg/kg/day resulted in an increase in hemoglobin, in the number of red blood cells and a decrease in reticulocyte levels. Hemolysis of Parquetina nigrescens extract-treated rats was lower than that of untreated rats, while their osmotic resistance was high. This indicates the presence of young red cell cells in the treated rats than in the control rats. These results confirm and validate the therapeutic indication of Parquetina nigrescens in the fight against anemia in traditional medicine.
Parquetina nigrescens, anemia, hemoglobin, reticulocytes, osmotic resistance.
HOW TO CITE THIS ARTICLE
Angèle GP, Calixte B, Richard KK, Justine TW, Marcellin GR, Nazaire D, Adama C. Study of antianemic properties of Parquetina nigrescens (Apocynaceae) in wistar rats. J Phytopharmacol 2019; 8(5):216-219.
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