The Journal of Phytopharmacology, 2019;8(5):238-247 ; DOI:10.31254/phyto.2019.8506
Study of aqueous leaf extracts of Spondias mombin Linn. (Anacardiaceae) in gastric ulcer models and the possible mechanisms of action
Agbaje Esther Oluwatoyin1 , Ogunsanya Wuraola Deborah1
1. Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria
*Author to whom correspondence should be addressed.
Received: 8th June, 2019 / Accepted: 13th October, 2019
Spondias mombin L. (Anacardiaceae) commonly known as ?yellow mombin? is a multipurpose herb cultivated in parts of the Brazilian Northeast for its edible fruits, oil and leaves. The bark is used to carve figures and the leaves and roots used as medicine. The objective of this study was to evaluate the effect of aqueous leaf extract of Spondias mombin Linn. on gastric ulcers. The effect was evaluated in ibuprofen, alcohol and pylorus ligation-induced gastric ulcer models. The extract was administered orally at three different doses of 50, 100 and 200 mg/kg. The antiulcer activity was accessed in rats by comparing the ulcer index in the test group with that of the control (distilled water) and standard (omeprazole, misoprostol) groups. The involvements of endogenous nitric oxide, prostaglandins and non-protein sulfhydryl groups in the cytoprotective action of Spondias mombin L. were also investigated. The extract showed a significant (p
Gastric ulcer, extract, Spondias mombin, antioxidant, cytoprotection, antisecretory.
HOW TO CITE THIS ARTICLE
Oluwatoyin AE, Deborah OW. Study of aqueous leaf extracts of Spondias mombin Linn. (Anacardiaceae) in gastric ulcer models and the possible mechanisms of action. J Phytopharmacol 2019; 8(5):238-247.
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