The Journal of Phytopharmacology, 2018;7(5):404-411 ; DOI:10.31254/phyto.2018.7501
Kalanchoe pinnata aqueous extract safety and potential cardioprotective effects in isoprenaline treated rats
Désiré Paul Djomeni Dzeufiet1 , Théophile Dimo1 , Orelien Sylvain Mtopi Bopda2 , Nathalie Nadège Chendjou Koumtouzi2 , Danielle Bilanda1 , Christian Tiambo Keambou2
1. Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon
2. Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, Buea, Cameroon
*Author to whom correspondence should be addressed.
Received: 7th August, 2018 / Accepted: 10th October, 2018
Introduction: Kalanchoe pinnata (Crassulaceae) aqueous extract antihypertensive property has been proven. This study aimed to evaluate the safety and potential cardioprotective effects of the extract in isoproterenol treated rat. Methods: A total of 35 adult wistar rats were randomly and evenly distributed into groups 1-7 then treated for 28days. Control groups 1-3 received 10mL/kg water (per os, neutral), 150mg/kg isoproterenol (ISO, sc, 48 and 24hours prior to sacrifice, negative) and ISO plus 10mg/kg propranolol (per os, ten days prior to sacrifice, positive). Safety test groups (4-6) received K. pinnata extract (50, 100 and 200mg/kg per os). Cardioprotective test group 7 received K. pinnata (100mg/kg per os) and ISO. The sacrifice of rats was carried out on day 29 and blood collected for haematological and biochemical analyses. Liver, kidney and heart were collected weighed and preserved for histopathological analysis. Results: There was no observable sign of toxicity. No significant difference was observed between the relative weight of the heart from groups 1-7. The platelet value dropped from 794.7x10 /L (group 2) to 284x10 /L (group 7, p
K. pinnata; safety; myocardial infarction; cardioprotective effects; rat
HOW TO CITE THIS ARTICLE
Bopda OSM, Koumtouzi NNC, Bilanda D, Dzeufiet DPD, Keambou CT, Dimo T. Kalanchoe pinnata aqueous extract safety and potential cardioprotective effects in isoprenaline treated rats. J Phytopharmacol 2018; 7(5):404-411.
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