The Journal of Phytopharmacology, 2017;6(2):98-101 ; DOI:10.31254/phyto.2017.6206
Antiviral activities of Cucumis metuliferus fruits alkaloids on Infectious Bursal Disease Virus (IBDV)
Anne A. Anyanwu1 , Nanloh S. Jimam2 , Simeon Omale2 , Noel N. Wannang1
1. Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Jos, Jos, Nigeria
2. Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Jos, Jos, Nigeria
*Author to whom correspondence should be addressed.
Received: 3rd April, 2017 / Accepted: 31st May, 2017
Objective: The toxicity of the alkaloids isolated from the fruit pulp of Cucumis metuliferus was investigated in chicken fibroblast cells. Materials and Methods: The alkaloids from C. metuliferus fruit pulp were isolated and their effects assayed on infectious bursal disease virus (IBDV) using chicken ebryo fibroblast cells. Results: There was no observed structural change on the chicken fibroblast cells when exposed to concentrations of 0.195 and 100 mg/ml of the alkaloids; and there was observed antiviral activities on IBDV at concentration between 6.125 and 100 mg/ml, while concentrations of the alkaloids between 0.195 to 3.125 mg/ml showed no antiviral activities compared to the control. Conclusion: The alkaloid showed good margin of safety on chicken fibroblast cells, with antiviral activities on infectious bursal disease virus (IBDV).
Alkaloids,Chicken fibroblast cells, Cytotoxicity, C. metuliferus, Infectious bursal disease virus.
HOW TO CITE THIS ARTICLE
Anyanwu AA, Jimam NS, Omale S, Wannang NN. Antiviral activities of Cucumis metuliferus fruits alkaloids on Infectious Bursal Disease Virus (IBDV). J Phytopharmacol 2017;6(2):98-101.
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