ISSN: 2320-480X
Manuscript Submission

The Journal of Phytopharmacology, 2014;3(3):204-213 ;   DOI:10.31254/phyto.2014.3308

Research Article

Psychopharmacological studies of Mammea africana stem bark extract

Jude E. Okokon1 , Koofreh Davies2

1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
2. Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria

*Author to whom correspondence should be addressed.

Abstract


Herbal medicine is an integral part of the health care system in most developed and developing countries of the world. Objective: The stem bark of Mammea africana used traditionally in the treatment of mental disorders was evaluated for depressive effect on the central nervous system (CNS). Materials and Method: The stem bark extract was investigated for depressive activity in the open field, force swimming and tail suspension tests as well as its anticonvulsant potential against pentylene tetrazol and aminophylline-induced convulsions. The effect of the extract on phenobarbitone induced sleeping time was also evaluated. Results: The extract was found to significantly (p

Keywords

Mammea africana, Depressant, Sedation, Anticonvulsant, Convulsion.


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY 4.0) license. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (http://creativecommons.org/licenses/by/4.0/).

Copyright

Copyright © 2014 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.

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