The Journal of Phytopharmacology, 2015;4(2):73-79 ; DOI:10.31254/phyto.2015.4203
Antiplasmodial and antidiarrhoeal activities of Dicliptera verticillata leaf extract
Ettebong Ette1 , Etuk E.U1 , Ubulom Peace2 , Ekpenyong Chris3 , Okokon J.E1 , Udobi C. E2 , Nnadi Eucharia1 , Akpan Idorenyin1 , Akpan Sifonobong1 , Malachy Nsikan1 , Attah Susannah1
1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, P. M .B. 1017, University of Uyo, Uyo, Nigeria
2. Pharmaceutical Microbiology and Parasitology Unit, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
3. Department of Physiology, Faculty of Basic Medical Sciences, School of Health Sciences, University of Uyo, Uyo, Nigeria
*Author to whom correspondence should be addressed.
Dicliptera verticillata (Forssk) Ch. (Acanthaceae) (leaf) is used as a traditional medicine for the treatment of malaria and diarrhoea in Burkina Faso and among the Ibibios of southern Nigeria. This study was aimed at evaluating the antiplasmodial activities of the ethanol leaf extract of Dicliptera verticillata in Plasmodium berghei infected mice and antidiarrhoeal activity in rats. Suppressive, repository and curative tests were used in determining the antiplasmodial activities in mice following oral administration of the extract (290, 580 and 870 mg/kg). Chloroquine (5 mg/kg) and Pyrimethamine (1.2 mg/kg) were used as standard drugs. The antidiarrhoeal activity of the extract (290, 580, and 870 mg/kg) was evaluated using castor oil-induced diarrhea, fluid accumulation and intestinal transit models. Loperamide (3 mg/kg) and atropine (3 mg/kg) were used as positive controls. The extract showed a dose dependent antiplasmodial activity in the suppressive, repository and curative tests. The mean survival time of the groups treated with extract increased in a dose dependent fashion from 14.33 to 19.33 days compared to control. These results were statically significant (p
Antiplasmodial, Antidiarrhoeal, Dicliptera verticillata.
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