The Journal of Phytopharmacology, 2015;4(2):87-89 ; DOI:10.31254/phyto.2015.4205
In-vitro thrombolytic and cytotoxic activity of methanolic extract of Syzygium operculatum leaves
Md. Ibrahim Tarek1 , Abul Hasanat1 , Mohammad Shah Hafez Kabir1 , Tanvir Ahmad Chowdhury1 , Mizanur Rahman2 , Md. Mir Ezharul Hossain3
1. Department of Pharmacy, International Islamic University Chittagong (IIUC), Chawkbazer, Chittagong-4203, Bangladesh
2. Department of Pharmacy, North South University (NSU), Dhaka, Bangladesh
3. Professor, Department of Pharmacy, International Islamic University Chittagong (IIUC), Chawkbazer, Chittagong-4203, Bangladesh
*Author to whom correspondence should be addressed.
The existing study was made to investigate the thrombolytic exercise and cytotoxic potential with the methanol extract of Syzygium operculatum leaves. The cytotoxicity had been assessed while using brine shrimp lethality bioassay and also thrombolytic impact with individual blood. The brine shrimp lethality bioassay was employed to evaluate cytotoxicity (LC50=272.82?g/ml) compared to vincristine associated with sulphate (LC50=0.512?g/ml). It had been also assessed as thrombolytic agent compared to streptokinase. It's got Significant thrombolytic exercise (36. 28%) compared to standard streptokinase (75.09%).
Thrombolytic, Cytotoxic, Clot lysis, Syzygium operculatum.
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