The Journal of Phytopharmacology, 2015;4(3):143-146 ; DOI:10.31254/phyto.2015.4303
Hepatoprotective activity of Somanathi Tamra Bhasma in paracetamol induced liver toxicity in albino- rats
Sudheendra Honwad1 , T Shridhara Bairy2 , Ravi M3 , B Ravishankar4
1. Ph.D. Scholar, Dept of Dravyaguna S.D.M. College of Ayurveda, Kuthpady, Udupi574118, India
2. Prof. and Head, Dept of Dravyaguna S.D.M. College of Ayurveda, Kuthpady, Udupi574118, India
3. Senior Research Officer, S.D.M. Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi-574118, India
4. Director, S.D.M. Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi574118, India
*Author to whom correspondence should be addressed.
To Investigate the hepatoprotective activity of Somanathi Tamra Bhasma against paracetamol induced hepatotoxicity. The hepatoprotective activity of Somanathi Tamra Bhasma was tested against paracetamol induced hepatotoxicity in albino rats. The degree of protection was determined by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transminase (SGOT), Serum glutamate pyruvate transminase (SGPT), alkaline phosphate (ALP) etc., and histopasthological studies. Silymarin was used as standard drug for comparison. Administrationof Somanathi Tamra Bhasma (67.5 mg/1kg. Bd. Wt.) markedly prevented paracetamol induced elevation of levels of SGOT, SGPT and alkaline phosphate etc,. The results are comparable to that ofsilymarin. A comparative histopathological study of liver exhibited almost normal architecture as compared to control group. Treatment with Somanathi Tamra Bhasma significantly reduced the paracetamol induced hepatotoxicity. A comparative histological study of liver from different groups further confirmed the hepatoprotective activity of Somanathi Tamra Bhasma.
Hepatoprotective; Somanathi Tamra Bhasma; Paracetamol
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