The Journal of Phytopharmacology, 2021;10(3):192-195 ; DOI:10.31254/phyto.2021.10308
Effect of concurrent exposure of toxic concentrations of lead and endosulfan on oxidative stress indices in rats
Ranganathan V1 , Malik JK2 , Rao GS3
1. Professor and Head, Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Orathanadu, Thanjavur-614 625, Tamil Nadu, India
2. Principal Scientist (Retired), Division of Veterinary Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly -243122, Uttar Pradesh, India
3. Professor and Head, Department of Veterinary Pharmacology and Toxicology, NTR College of Veterinary Science, Gannavaram-521102, Andhra Pradesh, India
*Author to whom correspondence should be addressed.
Received: 14th April, 2021 / Accepted: 4th May, 2021
The effect of concurrent exposure of toxic concentrations of lead and endosulfan were evaluated on oxidative stress parameters in male wistar rats. Group I served as untreated control whereas Group II received drinking water containing lead as lead acetate @1000 ppm (Pb1000). Group III was exposed to feed containing technical grade endosulfan @ 100 ppm (E100). Group IV was exposed to Pb (1000) +E (100). All the treatments were given daily for 28 days. Combination of lead and endosulfan modified the indices of oxidative stress in the parameters such as lipid peroxidation, reduced glutathione, superoxide dismutase and catalase in rats as compared to their individual compounds. The results suggest that the combination of these individual compounds may have the potential to modify oxidative stress produced by single compounds in male rats.
Lead, Endosulfan, Oxidative stress, Rats, Lipid peroxidation.
HOW TO CITE THIS ARTICLE
Ranganathan V, Malik JK, Rao GS. Effect of concurrent exposure of toxic concentrations of lead and endosulfan on oxidative stress indices in rats. J Phytopharmacol 2021; 10(3):192-195.
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