The Journal of Phytopharmacology, 2022;11(3):159-163 ; DOI:10.31254/phyto.2022.11305
Phytochemical screening and effects of aqueous extract of Acalypha wilkesiana Müll. Arg on isolated toad heart
Wensleslace Landry Mve Mendame1 , Boris Achille Eyi Mintsa1 , Alban-Michel Nguema Nguema1 , Arnaud Brice Pambo-Pambo1 , Ibrahim2
1. Laboratoire de Physiologie Animale : Electrophysiologie-Pharmacologie, Unité de Recherche Agrobiologie, Université des Sciences et Techniques de Masuku (USTM), BP 943 Franceville, Gabon
2. Laboratoire de Physiologie Animale: Electrophysiologie-Pharmacologie, Unité de Recherche Agrobiologie, Université des Sciences et Techniques de Masuku (USTM), BP 943 Franceville, Gabon
*Author to whom correspondence should be addressed.
Received: 16th March, 2022 / Accepted: 13th May, 2022 / Published : 7th June, 2022
Medicinal plants are real sources of bioactive molecules. The objective of the present study was to assess the effects of aqueous extract of Acalypha wilkesiana (ALWILEXT) on toad heart. Phytochemical screening of the aqueous extract revealed the presence of bioactives, namely: coumarins, flavones, polyphenols, alkaloids, tannins, terpenes and saponosides. The results obtained show that ALWILEXT, at concentrations ranging from 5.10-5 to 5.10-5g / ml, causes negative inotropic and chronotropic effects on the isolated toad heart, similar to those of acetylcholine although less marked. These effects suggest the presence of adrenomimetics in the aqueous extract. The aqueous extract of Acalypha wilkesiana is said to contain concomitantly adrenomimetics which would justify its use in the treatment of hypertension.
Acalypha Wilkesiana, Phytochemical Screening, Inotropic, Chronotropic, Heart.
HOW TO CITE THIS ARTICLE
Mendame WLM, Mintsa BAE, Nguema AMN, Arnaud Brice Pambo-Pambo1 Ibrahim ABPPE. Phytochemical screening and effects of aqueous extract of Acalypha wilkesiana Müll. Arg on isolated toad heart. J Phytopharmacol 2022; 11(3):159-163. doi: 10.31254/phyto.2022.11305
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