The Journal of Phytopharmacology, 2022;11(4):247-254 ; DOI:10.31254/phyto.2022.11404
Ameliorative Potentials of Bambusa vulgaris Leaf Extract on Carbon tetrachloride Induced Toxicity in Albino Rats
Temidayo Ogunmoyole1 , Oluwatobi Afolayan2 , Toluwalase Ajayi2 , Omowunmi Jayeola Makun3
1. Department of Medical Biochemistry, College of Medicine, Ekiti State University, Ado Ekiti, Ekiti State, Nigeria
2. Department of Science Laboratory Technology, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria
3. Department of Environmental Management and Toxicology, Federal University of Petroleum Resources, Effurun, Delta State, Nigeria
*Author to whom correspondence should be addressed.
Received: 25th June, 2022 / Accepted: 19th July, 2022
Bambusa vulgaris has been widely utilized in folkloric medicine for the treatment several diseases. Thepresent study evaluates the ameliorative effects of its leaves extract on carbon tetrachloride (CCl4)induced organs’ damage. This was done to provide a cost-effective and potent therapeutic option in themanagement of multi-organ disorders. Twenty Wistar rats were placed into five groups (I-V) of fouranimals each. All experimental animals, except group I were administered a single intraperitoneal doseof CCl4 (3 ml/kg b.w.). Animals in groups III and IV were treated with B. vulgaris at 200 mg/kg b.w.and 400 mg/kg b.w. respectively, group V animals received 100 mg/kg b.w. silymarin after initialexposure, while group II animals were left untreated after initial exposure to CCl4. Specific markers ofliver, kidney and heart injury such as alanine aminotransferase (ALT), alkaline phosphatase (ALP),lactate dehydrogenase (LDH), aspartate aminotransferase (AST), catalase, glutathione peroxidase, urea,creatinine, bilirubin and cytokines were assayed in the serum and tissue homogenates. Results indicatethat carbon tetrachloride caused a significant increase in the serum level of AST, ALP, ALT, LDH aswell as bilirubin, urea and inflammatory cytokines relative to control. On the other hand, activity ofglutathione peroxidase and catalase were diminished following exposure to CCl4. However, treatmentwith the B. vulgaris extract restored to all deranged biochemical indices to values comparable withanimals treated with silymarin. Histopathological evidence lends credence to the ameliorative potentialof B. vulgaris leaf extract on damaged liver, heart and kidney. Hence, B. vulgaris can be considered aviable therapeutic agent for the management/treatment of renal, cardiac and hepatic diseases.
B. Vulgaris, Liver, Restored, Serum, Diseases, Silymarin
HOW TO CITE THIS ARTICL
Ogunmoyole T, Afolayan O, Ajayi T, Makun OJ. Ameliorative Potentials ofBambusa vulgaris Leaf Extract on Carbon tetrachloride Induced Toxicity in AlbinoRats. J Phytopharmacol 2022; 11(4):247-254. doi: 10.31254/phyto.2022.11404
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