The Journal of Phytopharmacology, 2022;11(4):255-259 ; DOI:10.31254/phyto.2022.11405
Hepatoprotective activity of Amalakyadi Gana, a polyherbal ayurvedic formulation in paracetamol-induced hepatotoxicity in mice
Shreyosi Ray1 , Amit K. Taraphdar2 , Mradu Gupta3
1. Department of Dravyaguna, Raghunath Ayurved Mahavidyalaya and Hospital, Contai, Purba Medinipur-721401, West Bengal, India
2. Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education & Research, 294/3/1, Acharya Prafulla Chandra Road 700009, Kolkata, India
3. Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education & Research, 294/3/1, Acharya Prafulla Chandra Road-700009, Kolkata, India
*Author to whom correspondence should be addressed.
Received: 15th July, 2022 / Accepted: 2nd August, 2022
Since ancient times, Amalakyadi Gana, a polyherbal formulation of Susruta Samhita (6th century BCE),has been used for the prevention and treatment of numerous gastrointestinal diseases. This formulationconsists of fruits of Phyllanthus emblica, Terminalia chebula, Piper longum, and the root of Plumbagozeylanica. The hepatoprotective efficacy of this formulation was evaluated following the acute toxicitystudy in mice to validate its ayurvedic uses. The hepatoprotective efficacy was assessed usingparacetamol-induced hepatotoxicity in Swiss albino mice. Research drug exhibited in normalizing thePCM-dependent rise of serum liver function markers. After administration of the aqueous extract ofAmalakyadi Gana, relevant blood biochemical measures showed significant (P < 0.05) hepatoprotectiveactivity in a dosage-dependent manner, especially at the dose of 700 mg/kg orally in mice. Whencompared to the control group, significant (p < 0.05) histological alterations were also observed in theliver tissues. This formulation exhibited results in normalizing the liver architecture by decreasingnecrotic foci along with the normal liver parenchymal structure in the research drug pre-treated groupsmainly at the dose of 700 mg/kg, caused due to paracetamol toxicity. The research drug's sustainedactivity was comparable to that of the silymarin (200 mg/kg, p.o.) reference medicine. This formulationpossesses significant hepatoprotective activity without any toxicity in mice.
Amalakyadi Gana, Hepatoprotective, Phyllanthus emblica, Terminalia chebula, Piper longum, Plumbago zeylanica
HOW TO CITE THIS ARTICLE
Ray S, Taraphdar AK, Gupta M. Hepatoprotective activity of Amalakyadi Gana, apolyherbal ayurvedic formulation in paracetamol-induced hepatotoxicity in mice. JPhytopharmacol 2022; 11(4):255-259. doi: 10.31254/phyto.2022.11405
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