The Journal of Phytopharmacology, 2022;11(4):289-294 ; DOI:10.31254/phyto.2022.11412
Pharmacological Role of Heterocyclic Compounds in the Treatment of Alzheimer’s Disease: A Review
1. Assistant professor, Department of Biotechnology, Pushkaram College of Agriculture Sciences, Pudukkottai622303, India ORCID: 0000-0001-8977-2012
*Author to whom correspondence should be addressed.
Received: 20th May, 2022 / Accepted: 23rd June, 2022
Alzheimer’s disease (AD) is a multifactorial neurological disease that mainly affects the old age people.Neuropathologically, AD is characterized by low level of acetylcholine, loss of synapses and neurons incertain brain regions, accumulation of extracellular amyloid beta peptide (A?) and phosphorylation ofintracellular tau protein. Patients with AD are characterized by various symptoms such as memorydeficits, depression, cognitive dysfunction and difficult to perform daily activities. Currently availabledrugs for the treatment of AD are used to treat symptomatic relief at an early stage, however theprolonged usage of the drugs may cause adverse side effects. To overcome this, development of drugsproduced from natural products is considered as one of the promising alternatives for the treatment ofAD. Among that heterocyclic compound play a major role in the development of therapeutic drugsagainst various disorders. An organic compound which is cyclic or non-cyclic consists of one or moreatoms in their ring structure are known as heterocyclic compounds. These heterocyclic compounds occurboth in natural and synthetic form and play a major role in the metabolism of all living cells. Most of theorganic compounds used as drugs have a heterocyclic core in their skeleton. Nitrogenous bases such aspurines and pyrimidines present in DNA, chlorophyll, vitamins contain heterocycle in their structure.Other compounds containing heterocycles are proline, morphine, furan, vinblastine, cephalosporin,penicillin etc. This review summarizes the nomenclature, classification, and the role of heterocycliccompounds in the treatment of Alzheimer's disease.
Alzheimer’s Disease (AD), AD Pathology, Heterocyclic Compounds, Classification of Heterocycle, Role of Heterocycles Against AD
HOW TO CITE THIS ARTICLE
Palaniappan SP. Pharmacological Role of Heterocyclic Compounds in the Treatmentof Alzheimer’s Disease: A Review. J Phytopharmacol 2022; 11(4):289-294. doi:10.31254/phyto.2022.11412
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