The Journal of Phytopharmacology, 2022;11(5):347-352 ; DOI:10.31254/phyto.2022.11506
Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax
Frank Rwegoshora1,2 , Faith Mabiki1 , Francis Machumi3 , Musa Chacha4 , Bjarne Styrishave2 , Claus Cornett2
1. Department of Chemistry and Physics, College of Natural and Applied Sciences, Sokoine University of Agriculture, P. O. Box 3038 Morogoro Tanzania
2. Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2100 Copenhagen, Denmark
3. Department of Natural Products Development and Formulation, Institute of Traditional Medicine, Muhimbili University of Health and Allied Science, P.O. Box 65001, Dar es Salaam
4. School of Life Sciences and Bioengineering, The Nelson Mandela Institute of Science and Technology, P.O. Box 447, Arusha –Tanzania
*Author to whom correspondence should be addressed.
Received: 25th August, 2022 / Accepted: 2nd October, 2022 / Published : 31st October, 2022
The use of plants as sources of drug agents is attributed by factors among which are the easyaccessibility to plants, less toxicity and little or no drug resistance. An improvement in both traditionalmedicine and drug discovery field necessitates investigation of pure compounds in any plant withmedicinal value. Synadenium glaucescens Pax of the family Euphorbiaceae is among the medicinal plantin Tanzania which are proven to contain bioactive compounds against microbial infections. Analysis ofethanolic and methanolic extracts of root and stem barks respectively aided to isolated six purecompounds (SG1- 6). These compounds were analyzed by both 1D, 2D NMR and GC-MS while theirspectral processing was achieved in the Bruker TopSpin 3.6.2. Among these compounds, one was aphenolic (hemicosanyl ferulate-SG1), three triterpenoids, (lupeol- SG2, epifriedelanol- SG4 and eupholSG5), one steroid (?-sitosterol- SG6) and a long chain alkene (1-nonacosene- SG2). Cytotoxicityevaluation by Brine shrimp lethality test (BLST) indicated the compounds under report were practicallynon-toxic.
Triterpene, Lupeol, Friedelanol, NMR, Euphorbiaceae, Brine shrimp.
HOW TO CITE THIS ARTICLE
Rwegoshora F, Mabiki F, Machumi F, Chacha M, Styrishave B, Cornett C. Isolationand toxicity evaluation of feruloyl ester and other triterpenoids from Synadeniumglaucescens Pax. J Phytopharmacol 2022; 11(5):347-352. doi:10.31254/phyto.2022.11506
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