The Journal of Phytopharmacology 2024; 13(2):154-159 ; DOI:10.31254/phyto.2024.13209
Thermoxidized palm oil diet (TPO) induced protein derangements in rats is ameliorated by fresh palm oil (FPO) and Vitamin E
Imoh Emmanuel Ukoh1 , Idongesit Bassey Umoh2 , Enene Esu Ukpai3 , Samuel Kelechi Mobisson4 , Ikete Precious Whiskey1 , Perowei Azosibe1 , Azibaobom Karibi1 , Ukrakpo Oghenemega Sophia1 , Adienbo Emmemodi Nwadighi1
1. Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Federal University Otuoke, Otuoke, Bayelsa State, Nigeria
2. Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria
3. Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Cross River State University, Ogoja, Cross River State, Nigeria
4. Department of Human Physiology, Faculty of Basic Medical Sciences, Madonna University, Elele, Rivers State, Nigeria
*Author to whom correspondence should be addressed.
Received: 6th February, 2024 / Accepted: 24th April, 2024 / Published : 30th April, 2024
Objective(s): The therapeutic efficacy of FPO and vitamin E were studied against TPO induced derangements in some proteins in rats. Materials and Methods: 60 male albino rats (140-160g) weight range, grouped (n=10) as: Control, TPO, FPO, Vitamin E, TPO treated with FPO (TPO+FPO) and Vitamin E (TPO+ Vitamin E). TPO and FPO (15g each) mixed with 85g rat feed was used to prepare FPO and TPO diet. Vitamin E was administered 200mg/kg daily by oral gavage. Animals were fed for 4 weeks, while group 5 and 6 were further treated with FPO and Vitamin E for another 4 weeks. At the end of the experiment blood were collected from sacrificed rats via cardiac puncture and protein indices were analyzed using serum. Results: Sero-protein analysis revealed a significant reduction in total protein, albumin, globulin and albumin-globulin ratio in TPO compared to control, FPO and Vitamin E, but was significantly increased in TPO+FPO and TPO+ Vitamin E compared to TPO. Total protein was significantly increased in TPO+FPO compared to TPO+ Vitamin E, while globulin was significantly increased in TPO+ Vitamin E compared to TPO+FPO. Total bilirubin and unconjugated bilirubin were significantly increased in TPO compared to control, FPO and Vitamin E, but was significantly reduced in TPO+FPO and TPO+ Vitamin E compared to TPO. Total bilirubin was significantly reduced in TPO+FPO compared to TPO+ Vitamin E. Conjugated bilirubin was significantly reduced in TPO compared to control, FPO and Vitamin E, but was significantly increased in TPO groups treated with FPO and Vitamin E in relation to TPO. Conclusion: FPO and vitamin E displayed therapeutic efficacy in ameliorating protein derangements instigated by TPO consumption.
Fresh palm oil, Vitamin E, Protein indices, Derangement
HOW TO CITE THIS ARTICLE
Ukoh IE, Umoh IB, Ukpai EE, Mobisson SK, Whiskey IP, Azosibe P, Azibaobom Karibi, Sophia UO, Nwadighi AE. Thermoxidized palm oil diet (TPO) induced protein derangements in rats is ameliorated by fresh palm oil (FPO) and Vitamin E. J Phytopharmacol 2024; 13(2):154-159. doi: 10.31254/phyto.2024.13209
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