The Journal of Phytopharmacology, 2022;11(2):137-141 DOI:10.31254/phyto.2022.11216

Research Article

Comparative Haematological Effect of Seed and Stem Bark Extracts of Carapa procera D.C Meliaceae in Male Rodents

Azibanasamesa D.C Owaba¹ , Emmanuel I. Etim² , Ekarika C. Johnson²

Azibanasamesa D.C Owaba,Emmanuel I. Etim,Ekarika C. Johnson

1. Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria
2. Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Akwa-Ibom State, Nigeria

*Author to whom correspondence should be addressed.

Received: 31st March, 2022 / Accepted: 19th April, 2022

Abstract

Background: Blood system plays a vital role in the survival of mammals. Carapa procera is a medicinal plant which the seed is used in treatment of malaria while stem bark is used for the management of male erectile dysfunction in folkloric medicine. Objective: Evaluation of the hematological parameter is a tool to assess toxicity and to corroborate the safety or otherwise of this medicinal plant in humans. Methods: The seed and stem bark were collected from the wild and extracted using cold maceration and LD50 were determined using Lorke’s method. The extracts and fractions were administered at a dose of 86.60, 173.21, 259.81 for crude seed extract, while fraction was administered at a dose of 173.21 mg/kg/day while the crude stem bark was administered at 44.72, 89.44, 134.16 mg/kg/day while the median dose was administered daily for all the fractions for 7 days. On the 8th day the rats were anaesthetized and blood sample collected via cardiac puncture. Results: The results of the assessment showed that the seed extract significantly suppresses the lymphocytes at p