The Journal of Phytopharmacology, 2020;9(4):236-241 DOI:10.31254/phyto.2020.9404

Research Article

Aphrodisiac properties of aqueous roots extract of Pycnocoma macrophylla Benth (Euphorbiaceae) in rat

Mboumwa PV¹ , Wankeu Nya M¹ , Massoma Lembè D¹ , Kenmogne H¹ , Koloko BL¹ , Ngaha Njila MI¹ , Bend EF¹ , Nde Z¹ , Nyonseu Nzebang DC¹ , Moundipa FP²

Mboumwa PV,Wankeu Nya M,Massoma Lembè D,Kenmogne H,Koloko BL,Ngaha Njila MI,Bend EF,Nde Z,Nyonseu Nzebang DC,Moundipa FP

1. Department of Animal Sciences, Faculty of Sciences, University of Douala, Cameroon
2. Department of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I

*Author to whom correspondence should be addressed.

Received: 23rd May, 2020 / Accepted: 9th June, 2020

Abstract

Erectile dysfunction (ED) is a real health problem for men worldwide. This work investigated the effects of aqueous roots extract of Pycnocoma macrophylla (Euphorbiaceae) on sexual behavior in rats. Twentyfive adults’ rats divided into five groups were treated orally for fourteen days with distilled water (5 ml/kg, control), sildenafil citrate (5 mg/kg) and the aqueous extract of P. macrophylla (100, 200 and 400 mg/kg b.w) respectively. Sexual behavior parameters such as mount latency (ML), intromission latency (IL), ejaculation latency (EL), post-ejaculatory intervals (PEI), mount frequency (MF), intromission frequency (IF), ejaculation frequency (EF) and mean interval of copulation (MIC) were evaluated in treated animals mated with receptive female at days 1, 7 and 14 of treatment. At day 14, serum testosterone was measured. The results indicated that, the aqueous extract of P. macrophylla and especially the dose of 200 mg/kg significantly (p