The Journal of Phytopharmacology, 2020;9(4):252-257 DOI:10.31254/phyto.2020.9407
Antiinflammatory and antioxidant evaluation of Maytenus senegalensis hydroalcoholic roots extract fractions in allergic asthma
Pascaline Kindji Kpoyizoun1 , Kossi Metowogo1 , Yendoubé T Kantati1 , Afiwa Missebukpo1 , Tchin Dare2 , Povi Lawson-Evi1 , Kwashie Eklu-Gadegbeku1 , Kodjo A Aklikokou1 , Elizabeth U Egu1
1. Department of Animal Physiology: Laboratory of Physiology and Pharmacology, Research Unit: Pathophysiology, Bioactive Substances and Safety. Faculty of Sciences, University of Lomé, Togo
2. Department of Pathological Anatomy and Cytology. Faculty of Health sciences, University of Lomé, Togo
*Author to whom correspondence should be addressed.
Received: 5th June, 2020 / Accepted: 27th July, 2020
The present work aims to evaluate the antiinflammatory and antioxidant activities of the Maytenus senegalensis (Lam.) roots hydroethanolic extract and to determine its active fraction. The total extract is fractioned in cold alcohol 75%. Phytochemical studies and in vitro antioxidant test are performed on the extract and obtained fractions. During 28 days, mice were sensitized and challenged with OVA to induce allergic airway inflammation. the anti-inflammatory effect of the plant extract and its fractions is assessed by differential white blood cell counts and histopathological examinations. Them antioxidant effect is evaluated in vivo by MDA and glutathione dosage. Qualitative and quantitative phytochemical tests showed that the extract and its fractions contain phenolics compounds. In vitro, both extract and its fractions expressed antioxidant activities. Treatment with M. senegalensis extract and its fractions significantly decreased inflammatory cells number in BALF, reduced MDA concentration and enhanced glutathione level (p
Allergic asthma, Maytenus senegalensis, Antiinflammatory, Antioxidant.
HOW TO CITE THIS ARTICLE
Kpoyizoun PK, Metowogo K, Kantati YT, Missebukpo A, Dare T, LawsonEvi P, et al. Antiinflammatory and antioxidant evaluation of Maytenus senegalensis hydroalcoholic roots extract fractions in allergic asthma. J Phytopharmacol 2020; 9(4):252-257.
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