The Journal of Phytopharmacology, 2018;7(1):1-4 DOI:10.31254/phyto.2018.7101

Research Article

Protective effect of Mollugo cerviana extract on liver markers in alloxan induced diabetic rats

N. Markkas¹ , Madhuramozhi Govindharajalu²

N. Markkas,Madhuramozhi Govindharajalu

1. Research scholar, P.G. and Research Department of Zoology, A.D.M. College for women (Autonomous) Velipalayam, Nagapattinam, Tamil Nadu, India
2. P.G. and Research Department of Zoology, A.D.M. College for women (Autonomous) Velipalayam, Nagapattinam, Tamil Nadu, India

*Author to whom correspondence should be addressed.

Received: 27th October, 2017 / Accepted: 19th December, 2017

Abstract

Diabetes mellitus is a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Liver is the central metabolic organ in body responsible for glucose homeostasis, diabetes leads to hepatic dysfunction. In the present study to investigate the protective effect of Mollugo cerviana extract on liver markers in alloxan induced diabetic rats. Hepatospecific enzymes (ALP, ALT and AST), protein and albumin content were activated when hepatocellular damage gave rise to abnormalities of liver function and these enzymes are remarkably increased in diabetic rats. Further confirmed in the histopathological studies of liver. Mollugo cerviana helps in parenchymal cell regeneration in liver, thus protecting membrane integrity and thereby minimizing enzyme leakage. Histopathological studies also supported the biochemical parameters. This result suggested that Mollugo cerviana possess potential hepato regenerating activity.