The Journal of Phytopharmacology, 2018;7(3):319-324 DOI:10.31254/phyto.2018.7315

Research Article

Preclinical aphrodisiac investigation of ethanol extract of Flueggea leucopyrus Willd. leaves

Sharad Vasantrao Usnale¹ , Kailash Radhesham Biyani²

Sharad Vasantrao Usnale,Kailash Radhesham Biyani

1. School of Pharmacy, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded, Maharashtra, India
2. Anuradha College of Pharmacy, Chikhli, Dist.-Buldhana, Maharashtra, India

*Author to whom correspondence should be addressed.

Received: 13th April, 2018 / Accepted: 24th May, 2018

Abstract

Sexual dysfunction is a widely found disorder worldwide now a day because of busy lifestyle and stress. Management of disease is somewhat difficult because of cost and shortage of effective treatment. In the present paper authors have investigated effect of ethanolic extract of Flueggea leucopyrus Willd. leaves as aphrodisiac potential on albino rats. The dried leaves of plant were extracted by cold maceration method using ethanol. It was investigated for in vivo aphrodisiac activity. Plant extract was administered at doses 200 and 400 mg/kg body weight for 45 days. The effect of extract on general mating behavior, potency test, morphological studies, organ weight and sperm motility were tested. The results were compared with standard reference sildenafil citrate. The acute toxicity of the drug extract was also checked. On oral administration of ethanol extract 200 and 400 mg/kg doses on 15th, 30th and 45th day of treatment in all treated groups significantly increased intromission latency, mounting frequency, ejaculatory latency and significantly decreased intromission latency, mounting latency, inter intromission interval and post ejaculatory interval. Test for potency showed significant increase in long flips, quick flips and erections. In all experimental animals morphological study showed significant increase in main and accessory reproductive organs weight and sperm motility. As compared to the control the prolonged treatments for all treated groups were highly effective. This showed that aphrodisiac activity has been shown by ethanol extract but it is less than the standard. The present study showed that ethanol extract of Flueggea leucopyrus Willd. leaf increase sexual behavior in rats. Thus it supports the claim for this drug as an aphrodisiac.