The Journal of Phytopharmacology, 2017;6(3):156-163 DOI:10.31254/phyto.2017.6301
Gastro-duodenal protective effect of aqueous leaf extract of Daucuscarota sativus Linn. (Apiaceae) in rats and its possible mechanism of action
Esther Oluwatoyin Agbaje1 , Muyiwa Samuel Fageyinbo1 , Olaitan Oladele Alabi1
1. Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, P.M.B. 12003, Idi-Araba-Lagos, Nigeria
*Author to whom correspondence should be addressed.
Received: 18th June, 2017 / Accepted: 21st July, 2017
Background: Daucuscarota sativus L. (Apiaceae) commonly known as ‘carrot’ is a multipurpose herb cultivated in different parts of the world for its edible roots, juice, oils and leaves. Carrot root as well as its leaves has been credited with many medicinal properties, including cleansing of the intestine and maintenance of acid-alkaline balance in the body. Carrot leaves also known as carrot tops or carrot greens have been used locally as a decoction for healing mouth sores, and in some cases, mixed with honey to clean festering wounds. The present study was therefore designed to evaluate the possible gastro-duodenal protective property of Daucuscarota sativus (DCS) aqueous leaf extract on laboratory-induced ulcers. Aqueous leaf extract prepared by maceration was orally administered one hour before ulcerogens in doses of 50, 100 and 200 mg/kg to groups of randomized adult rats of both sexes. Gastric ulcers were induced using pyloric ligation, methyleneblue, and acetic acid, while cysteamine, and indomethacin-histamine were separately employed for induction of duodenal ulcers in the animals. Positive controls were given standard drugs appropriate for each experimental model. Phytochemical screening of the freshly prepared extract was also carried out, as well as evaluating its antioxidant activity. In each of the models, the aqueous leaf extract of DCS showed a significant (p
Daucus carota sativus, Ulcerogen, Antioxidant, Anti-Ulcer, Lipid Peroxidation, Cytoprotective
HOW TO CITE THIS ARTICLE
Agbaje EO, Fageyinbo MS, Alabi OO. Gastro-duodenal protective effect of aqueous leaf extract of Daucuscarota sativus Linn. (Apiaceae) in rats and its possible mechanism of action. J Phytopharmacol 2017;6(3):156-163.
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