The Journal of Phytopharmacology, 2017;6(5):277-281 DOI:10.31254/phyto.2017.6504
Evaluation of the fertility activity of the aqueous leaves extract of Zanthoxylum macrophylla (Rutaceae) on male rats
Ngandjui Alphonse1 , Ngaha Njila Marie1 , Kenmogne Hubert1 , Koloko Brice Landry1 , Massoma Lembe Dieudonné1 , Bend Emma Fortune1 , Oundoum Oudoum Pierre1 , Domkam Judith2 , Moundipa Paul2 , Dimo Théophile2
1. Department of Animal Sciences, Faculty of Science, University of Douala, Douala, Cameroon
2. Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
*Author to whom correspondence should be addressed.
Received: 23rd August, 2017 / Accepted: 7th October, 2017
Zanthoxylum macrophylla, one of the useful medicinal plants in Cameroon, was scientifically conducted to find its aqueous extract leaves effect in some fertility parameters of male rats. 24 rats were randomly divided into 4 groups: Control, A, B and C group of six animals each. They received respectively 0, 100, 200 and 400 mg/kg body weight of aqueous extract of Z. macrophylla leaves on daily basis for 14 days. There were no significant changes on the body weight of treated animals. However, the weight of testis and the Daily Sperm Production respectively increased at dose of 200 mg/kg (P< 0.05 and P< 0.001) and 400 mg/kg (P< 0.01 and P< 0.001) while the weight of seminal vesicle and prostate also increased respectively at dose of 200 mg/kg (P< 0.05) and 400 mg/kg (P< 0.01) when compared to the control. The serum testosterone level significantly increased at the dose of 200 mg/kg (P< 0.01) and 400 mg/kg (P< 0.001) while the total cholesterol decreased at dose of 400 mg/kg (P< 0.05) when compared to the control. The serum protein decreased respectively at dose of 200 mg/kg (P< 0.01) and 400 mg/kg (P< 0.01) when compared to the control. The histological sections of the testis did not show any structural abnormalities in all treated animals. These results indicate that Zanthoxylum macrophylla could improve male reproductive activities.
Fertility, Zanthoxylum macrophylla, Androgene level, Sperm count.
HOW TO CITE THIS ARTICLE
Alphonse N, Marie NN, Hubert K, Landry KB, Dieudonné ML, Fortune BE et al. Evaluation of the fertility activity of the aqueous leaves extract of Zanthoxylum macrophylla (Rutaceae) on male rats. J Phytopharmacol 201 7 ; 6 ( 5):277 -281 .
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