The Journal of Phytopharmacology, 2014;3(2):124-129 DOI:10.31254/phyto.2014.3208

Research Article

Lipid Lowering potential of Andrographis paniculata (Nees)

Vijai Lakshmi¹ , Shishir Srivastav² , Ashok Kumar Khanna³ , Abbas Ali Mahdi¹ , Santosh Kumar Agarwala¹

Vijai Lakshmi,Shishir Srivastav,Ashok Kumar Khanna,Abbas Ali Mahdi,Santosh Kumar Agarwala

1. Department of Biochemistry, King George Medical University (KGMC), Lucknow 226003, India
2. Medicinal and Process Chemistry Division, Central Drug Research Institute (CDRI), Lucknow 226001, India
3. Biochemistry Division, Central Drug Research Institute (CDRI), Lucknow 226001, India

*Author to whom correspondence should be addressed.

Abstract

Aim: Atherosclerosis and associated complications is now the major cause of myocardial morbidity and mortality worldwide. Therefore we have selected the Andrographis paniculata for the development of lipid lowering drug. Material and Methods: The lipid lowering activity of mixture of andrographaloides isolated from the leaves of the Andrographis paniculata has been studied in Triton and cholesterol fed hyperlipidemic rats (in vivo). Results: Serum lipids were found to be lowered by andrographaloides (at 50 mg/kg.) in Triton WR-1339 induced hyperlipidemia in experimental animals. Chronic feeding of this mixture of andrographolides (at 25 mg/kg) in animals, simultaneously fed with high fat diet (HFD) for 30 days caused lowering in the lipid and apoprotein levels of very low density (VLDL) and low density lipoproteins (LDL) It has also increased high density lipoprotein (HDL). Andrographaloides activated lipolytic enzymes in plasma and liver lipids. The hypolipidemic activity of the andrographaloides mixture is mediated through increased faecal bile acid excretion and enhanced plasma lecithin-cholesterol acyl transferase activity. Conclusion: Mixture of Andrographolides was found to lower the lipids in experimental animals.