The Journal of Phytopharmacology, 2014;3(3):168-175 DOI:10.31254/phyto.2014.3303
COX and LOX inhibitory potential of Abroma augusta and Desmodium gangeticum
Rekha Bisht1 , S. Bhattacharya2 , Yusuf Ali Jaliwala3
1. Research Scholar, Uttarakhand Technical University, Dehradun248007, Uttarakhand, India
2. Global Institute of Pharmaceutical Education and Research, Kashipur244713, Uttarakhand, India
3. Oriental University, Indore453555, Madhya Pradesh, India
*Author to whom correspondence should be addressed.
The present study was aimed to evaluate the cyclooxygenase (COX) and lipoxygenase (LOX) inhibitory activity of Abroma augusta (AA) and Desmodium gangeticum (DG). Initially In-vivo anti-inflammatory activity of aqueous extract (AqE) of aerial parts of DG (100 mg/ml) and petroleum ether extract (PEE) of roots of AA (250 mg/ml) was assessed in carrageenan induced paw oedema model in albino wistar rats. In addition, each plant extract was evaluated for COX1, COX-2 and LOX inhibitory activity to determine the possible mechanism of their antiinflammatory activity. The results of the study demonstrated that each plant extract significantly (p
Desmodium gangeticum, Abroma augusta, Inflammation, Cyclooxygenase, Lipoxygenase.
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