The Journal of Phytopharmacology, 2014;3(3):180-192 DOI:10.31254/phyto.2014.3305

Research Article

Antiinflammatory and antioxidant activity of extracts and isolated compounds from Derris brevipes Benth (Baker)

Rajesh S.Telekone¹ , Mohib Khan²

Rajesh S.Telekone,Mohib Khan

1. Padm.Dr. D.Y. Patil College of Pharmacy, Akurdi, Pune 411044, India
2. Oriental College of Pharmacy, Sanpada, Mumbai 400705, India

*Author to whom correspondence should be addressed.

Abstract

The role of medicinal plants in promoting the ability of human health to cope with the unpleasant and difficult situations is well documented from ancient times till date all over the world. The purpose of this study is to define antioxidant and anti-inflammatory activity of chloroform, methanol extract and isolated flavonoid compounds 2’,4’-dihydroxy-4-methoxy-3’- prenyl chalcone (compound 1) and Leutolin (compound 2) from the methanol extract of Derris brevipes Benth (Baker). This study displayed potential total antioxidant capacity, reducing power, efficacy in scavenging singlet oxygen and nitric oxide radicals of extracts and isolated compounds. The study also revealed anti-inflammatory capability of extracts and compounds. Out of the two extracts, methanol extract showed higher antiinflammatory activity and of the two compounds compound 2 outscored compound 1 in antiinflammatory efficacy. As an antiinflammatory test molecule the efficacy of compound 2 was nearly equal to that of the standard ibuprofen. IC50 values for antioxidant activities were also less for methanol extract and compound 2 as compared to chloroform extract and compound 1. These results confirm the role of isolated flavonoids as promising free radical scavengers, potent antioxidants and antiinflammatory agents.