The Journal of Phytopharmacology, 2015;4(4):212-216 DOI:10.31254/phyto.2015.4404

Research Article

Anti-microbial and anti-inflammatory flavonoid constituents from the leaves of Lawsonia inermis

Manivannan R¹ , Aeganathan R.² , Prabakaran K.²

Manivannan R,Aeganathan R.,Prabakaran K.

1. Assistant Professor, Department of Chemistry, Government Arts College (Autonomous), Kumbakonam-612001, Tamilnadu, India
2. Research Scholar, Department of Chemistry, Government Arts College (Autonomous), Kumbakonam-612001, Tamilnadu, India

*Author to whom correspondence should be addressed.

Abstract

A chemical investigation on the leaves of Lawsonia inermis led to the isolation and identification of five known and rare flavonoids, apigenin (1), 5, 7, 4? - trihydroxy-6, 3?, 5?-trimethoxyflavone (2), pectolinarigenin (3), apigenin-7-O-?-D-glucoside (4), and pectolinarin (5). Their structures were established on the basis of chromatography and spectroscopic evidence and comparisons with literature data. Antimicrobial and carrageenan induced paw edema in male albino rats were determined. Compounds 4 and 5 showed the most powerful antimicrobial effect against Escherichia coli and Aspergillus flavus at the dose of 200 mg/kg. Compound 2 showed pronounced anti-inflammatory effects (3.17±0.15 after 3 h of injection), slightly higher than that of other four compounds.