The Journal of Phytopharmacology, 2016;5(2):38-44 DOI:10.31254/phyto.2016.5201

Research Article

Comparative anti-inflammatory activity of Clerodendrum serratum (Linn) Moon and Solanum xanthocarpum Schrad and Wendl in wistar ablino rats

Poornima Solapure¹ , Pradeep² , Ravi Mundugaru³ , Prakash L Hegde⁴

Poornima Solapure,Pradeep,Ravi Mundugaru,Prakash L Hegde

1. Assistant Professor, Department of Dravyaguna, Sri Dharmasthala Manjunatheshwara (SDM) College of Ayurveda, Hassan, Karnataka, 573201, India
2. Associate Professor and Head, Department of Dravyaguna, Sri Dharmasthala Manjunatheshwara (SDM) College of Ayurveda, Hassan, Karnataka, 573201, India
3. Research Officer; Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi-574118, India
4. Professor, Department of Dravyaguna, Sri Dharmasthala Manjunatheshwara (SDM) College of Ayurveda, Hassan, Karnataka, 573201, India

*Author to whom correspondence should be addressed.

Abstract

C. serratum and S. xanthocarpum plants are used as folk remedies for inflammations, arthritis, cough, asthma and bronchitis. The present investigation aimed to evaluate the comparative anti-inflammatory activity in Wistar albino rats. The group specific rats were treated for seven consecutive days and subjected to carrageenan induced paw oedema and cotton pellet implanted granuloma tissue formation tests at a dose of 8.64ml/kg (p.o). Both the test drugs have shown reduced paw volume during third and sixth hour readings and a moderate decrease in the granuloma tissue formation. CRP enzyme was found to be reduced significantly and a moderate elevation in white pulp of spleen from both the test groups were observed. The present findings suggest that both the drugs have moderate anti-inflammatory activity as ascertained by the comparative decrease in carrageenan induced paw volume, decreased granuloma tissue formation and normal histological profile of important organs.