ISSN: 2320-480X
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The Journal of Phytopharmacology, 2013;2(4): 8-12 DOI:10.31254/phyto.2013.2402

Research Article

Pharmacological evaluation of Sedative and Hypnotic activities of methanolic extract of Lycopus europaeus in mice

Abdul Aziz1 , Imran Ahmad Khan1

1. Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan

*Author to whom correspondence should be addressed.

Abstract


The methanolic extract of Lycopus europaeus was evaluated on central nervous system. The methanolic extract produced significant sedative effect at the doses of 200, 400 and 600 mg/kg (by oral route), compared to reference substance diazepam in hole board and thiopental -induced sleeping time methods. While the hypnotic effect was calculated at the doses of 800 and 1000 mg/kg via oral pathway significantly reduced in both the reestablishment time and number of head dips during the traction and hole-board tests. In conclusion, these results suggest that the methanolic extract of Lycopus europaeus possess potent sedative and hypnotic activities, which supported its therapeutic use for insomnia.

Keywords


Lycopus europaeus, Sedative, Hypnotic, Methanolic extract.

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Copyright © 2013 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 3.0.

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