The Journal of Phytopharmacology, 2013;2(4): 22-29 DOI:10.31254/phyto.2013.2404

Research Article

Phythochemical screening, antioxydant and antiplasmodial activities of extracts from Trichilia roka and Sapium ellipticum

O. Nana¹ , J. Momeni² , R. Nzangué Tepongning³ , M. B. Ngassoum⁴

O. Nana,J. Momeni,R. Nzangué Tepongning,M. B. Ngassoum

1. National Advanced School of AgroIndustrial Sciences, P. O. Box 455 Ngaoundere, Cameroon
2. Department of Chemistry, Faculty of Science, National Advanced School of Agro-Industrial Sciences, P. O. Box 454 Ngaoundere, Cameroon
3. Department of Chemistry, Faculty of Science, University of Ngaoundere, P. O. Box 454 Ngaoundere, Cameroon
4. Department of Biomedical Sciences, Faculty of Science, University of Ngaoundere, P. O. Box 454 Ngaoundere, Cameroon

*Author to whom correspondence should be addressed.

Abstract

Antiplasmodial and antioxidant activities of extracts derived from Trichilia roka (Chiov) root bark and Sapium ellipticum (Hochst) Pax root bark were determined respectively in vivo by Peters et al. methods and by DPPH radical-scavenging and ?-carotene-linoleate model systems. Of those extracts, the two methanolic extracts revealed a good antioxidant and the antiplasmodial activities. The T. roka methanolic extract was more effective than S. ellipticum extract concerning antiplasmodial activity and the S. ellipticum extract, the most promising one concerning antioxidant activity with IC50 42.18 ?g/ml better than BHT value IC50 83.36 ?g/ml taking as control. The high activities of these two plant extracts suggest that they are good source of natural antioxidant and may contain new compounds with lead structures for drug development against malaria.