The Journal of Phytopharmacology, 2013;2(6): 41-45 DOI:10.31254/phyto.2013.2607
Analgesic activity of aqueous extract of Vernonia hymenolepis (A. Rich) a traditional medicine plant used in Kenya for toothache
R.O. Onzago1 , S.G. Kiama2 , J.M. Mbaria1 , D.W Gakuya3 , C.G. Githiji4 , Z.M. Rukenya5
1. Department of Public Health Pharmacology and Toxicology, University of Nairobi, Nairobi, Kenya
2. Department of Veterinary Anatomy and Physiology, University of Nairobi, Nairobi, Kenya
3. Department of Clinical Studies, University of Nairobi, Nairobi, Kenya
4. Department of Medical Physiology, School of Medicine, College of Health Sciences, University of Nairobi, Nairobi, Kenya
5. Department of Public Health, Pharmacology and Toxicology, University of Nairobi, Nairobi, Kenya
*Author to whom correspondence should be addressed.
The main aim of the study was to ascertain the analgesic properties of Vernonia hymenolepis leaves to validate its use for the treatment of toothache. The plant is widely used as a traditional herb by communities in Trans Nzoia County, Kenya for treatment of various infections including toothache. However its efficacy has not been established. Leaves of the plant were collected from Trans Nzoia County, Kenya and identified at University of Nairobi Herbarium. An aqueous extraction of leaves was prepared. Formalin test was carried out using 30 male albino wister mice to determine antinociceptive effect and the painful response at 0 – 10 min (Early) and 15 – 60 min (late phase). Acetylsalicylate at dose of 100 mg/Kg was used as a positive control. The dose significantly (p
Vernonia hymenolepis, Analgesic, Anti-inflammatory, Antinociceptive.