The Journal of Phytopharmacology, 2022;11(5):341-346 DOI:10.31254/phyto.2022.11505
Spirulina platensis Inhibits Aflatoxin B1 Induced Biochemical Changes in Male Swiss Albino Mice
Masese Johnson1 , Kipkoech Gilbert2 , Mwitari Peter3 , Nguka Gordon4 , Mutai Charles5
1. School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science and Technology, P.O Box 190 – 50100, Kakamega Kenya
2. Department of Biochemistry, Biotechnology, Kenyatta University P.O Box 43844 - 00100, Nairobi, Kenya
3. Centre for Traditional Medicine and Drug Research, Kenya Medical Research Institute (KEMRI), P.O. Box 54840 - 00200, Nairobi, Kenya
4. Department of Nutritions and diatetics, School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science & Technology P.O Box 190 – 50100, Kakamega, Kenya
5. Department of Medical Laboratory Sciences, School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science & Technology P.O Box 190 – 50100, Kakamega Kenya.
*Author to whom correspondence should be addressed.
Received: 24th August, 2022 / Accepted: 13th October, 2022 / Published : 31st October, 2022
Aflatoxins (AF) are harmful metabolites produced by Aspergillums species principally by Aspergillus.flavus and Aspergillus parasiticus. Aflatoxins are hepatotoxic, teratogenic, mutagenic and carcinogenic.The main objective of the current study was to evaluate protective effects of Spirulina platensis extractagainst aflatoxin B1 (AFB1) induced biochemical changes in male Swiss albino mice. Randomly 25healthy inbred mice were allocated into five groups, each having 5 mice. Group I (Control group), micereceived normal diet. Group II mice received 100 mg/kg/day of S. platensis extract. Group III micereceived 200 µg/kg/day of AFB1. Group IV mice received S. platensis extract 100 mg/kg/day and 200µg/kg/day of AFB1. Group V mice received S. platensis extract 200 mg/kg/day and 200 µg/kg/day ofAFB1 for 28 days. Levels of alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartateaminotransferase (AST), globulin, albumin and total plasma protein were analyzed in blood samplesusing an automated biochemistry analyser. Data analysis was done using one way ANOVA with Tukey’sHonestly Significantly Differenced (HSD) post-hoc analysis. Statistical significance level was set atP
Spirulina platensis, aflatoxin B1, biochemical changes, protective effects.
HOW TO CITE THIS ARTICLE
Johnson M, Gilbert K, Peter M, Gordon N, Charles M. Spirulina platensis InhibitsAflatoxin B1 Induced Biochemical Changes in Male Swiss Albino Mice. JPhytopharmacol 2022; 11(5):341-346. doi: 10.31254/phyto.2022.11505
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