The Journal of Phytopharmacology, 2022;11(5):353-359 DOI:10.31254/phyto.2022.11507
Gastric acid anti-secretory activity of aqueous leaf extract of Hypoestes rosea in ulcer-induced rats
Egbe Agala Eja1 , Eyo Aniekan-Augusta Okon2 , Inyang Imeobong Joseph1 , Archibong Anietie Michael3
1. Department of Histopathology and Cytology, Faculty of Medical Laboratory Science University of Calabar, 540271. Nigeria
2. Department of Medical Bacteriology, Virology and Mycology, Faculty of Medical Laboratory Science University of Calabar, 540271. Nigeria
3. Department of Histopathology, University of Uyo Teaching Hospital, Uyo, Akwa Ibom State.
*Author to whom correspondence should be addressed.
Received: 31st July, 2022 / Accepted: 25th September, 2022 / Published : 31st October, 2022
Background: Hypoestes rosea, an evergreen shrub belonging to the Acanthaceae family possess antiulcer potential amongst its several other medicinal properties, including usefulness as anti-diabetic andanti-inflammatory agents. Objective: In this study, we investigated the anti-secretory effect of aqueousleaf extract of H. rosea as the possible mechanism for its antiulcer activity in gastric ulcer induced rats. Methods: 40 rats were divided into 2 experimental phases of 20 rats each. They were further separatedinto 5 groups as follows: Group 1 (Normal control: rat chow and water only). Group 2 Ulcer control:Indomethacin-induced (40mg/kg bw). Group 3: Low dose (100mg/kg bw). Group 4: Medium dose(200mg/kg bw). Group 5: High dose (300mg/kg bw). Phase 1 involved determination of ulcer lesionindex and % inhibition. Phase 2 involved estimation of gastric acid secretion using the method ofcontinuous perfusion with 10minutes aliquots titrated against 0.01N NaOH. Results: Aqueous extract ofHypoestes rosea produced a significant (P
Acanthaceae, gastric acid secretion, Histamine, Hypoestes rosea, Phytochemical evaluation.
HOW TO CITE THIS ARTICLE
Egbe AE, Eyo AO, Inyang IJ, Archibong AM. Gastric acid anti-secretory activity ofaqueous leaf extract of Hypoestes rosea in ulcer-induced rats. J Phytopharmacol2022; 11(5):353-359. doi: 10.31254/phyto.2022.11507
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