The Journal of Phytopharmacology 2023; 12(3):135-142 DOI:10.31254/phyto.2023.12301

Research Article

Aqueou Extract of the seeds of Pithecellobium dulce (Fabaceae) Demontrates Anti-inflammatory Effect Through Anti-oxydant Activity Enhancement in a Rodent Model of on Hemorrhoidal disease induced by Acetic Acid

Atsang A Kiki Gisèle¹ , Takvou Francis¹ , Egre Finsia¹ , Zramah Mathieu¹ , Dzeufiet DPD²

Atsang A Kiki Gisèle,Takvou Francis,Egre Finsia,Zramah Mathieu,Dzeufiet DPD

1. University of Maroua, Faculty of Science, Department of Biological Sciences, Maroua, Cameroon
2. University of Yaounde I, Faculty of Science, Department of Animal Biology, Yaounde, Cameroon

*Author to whom correspondence should be addressed.

Received: 21st March, 2023 / Accepted: 17th May, 2023 / Published : 30th June, 2023

Abstract

After the last treatment, all animals received 5 % acetic acid anal route to the hemorrhoidal submucosa. Administration of acetic acid resulted in a significant reduction (p ? 0.01; p < 0.001) in body weight and recto-anal coefficient at doses of 250 and 500 mg/kg compared to the negative control. In addition, the concentration of nitric oxide (NO), MDA were significantly reduced (p < 0.05 p < 0.01) in the groups pretreated with different doses of the extract (125, 250 and 500 mg/kg) compared to negative and normal control with a significant increase (p < 0.05 and p < 0.001) in the level of SOD, CAT and GHS compared to the negative control. Histological sections showed cellular regeneration in the anal mucosa.