The Journal of Phytopharmacology 2026; 15(3):174-189 DOI:10.31254/phyto.2026.15310
Ameliorative effects of medicinal plants on diabetes mellitus-induced male reproductive dysfunction in experimental animal models
Tanvi Jangid1 , Aditya Jain1 , Gauri Shankar Bhardwaj1 , Ram Niwas Jangir2
1. Research Scholar, Reproductive Physiology Lab, Department of Zoology, University of Rajasthan, Jaipur- 302004, Rajasthan, India
2. Assistant professor, Reproductive Physiology Lab, Department of Zoology, University of Rajasthan, Jaipur- 302004, Rajasthan, India
*Author to whom correspondence should be addressed.
Received: 28th April, 2026 / Accepted: 20th June, 2026 / Published : 6th July, 2026
Diabetes mellitus (DM) is a rapidly growing metabolic disorder characterized by chronic hyperglycemia and associated systemic complications. Increasing evidence indicates that DM adversely affects male reproductive health by impairing spermatogenesis, hormonal balance, and fertility, primarily through oxidative stress and metabolic disturbances. Conventional therapies remain essential but may not fully prevent long-term complications. Medicinal plants and their bioactive phytochemicals have gained attention due to their multi-targeted antidiabetic, antioxidant, and fertility-protective effects. A comprehensive literature search was conducted using major scientific databases, including PubMed, Scopus, Web of Science, and Google Scholar, to identify relevant studies on medicinal plants that ameliorate diabetes induced male reproductive dysfunctions. Findings from these database-indexed studies indicate that numerous medicinal plants and polyherbal formulations exhibit significant antidiabetic and fertility-protective effects, mainly through antioxidant, anti-inflammatory, and glycemic regulatory mechanisms. This review summarizes recent evidence on medicinal plants and polyherbal formulations that improve glycemic control and male reproductive functions in diabetic conditions, highlighting their therapeutic mechanisms and potential clinical relevance.
Diabetes mellitus, Male reproductive dysfunction, Medicinal plants, Oxidative stress, Antioxidants, Spermatogenesis.
HOW TO CITE THIS ARTICLE
Jangid T, Jain A, Bhardwaj GS, Jangir RN. Ameliorative effects of medicinal plants on diabetes mellitus-induced male reproductive dysfunction in experimental animal models. J Phytopharmacol 2026; 15(3):174-189. doi: 10.31254/phyto.2026.15310
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