The Journal of Phytopharmacology, 2020;9(6):385-391 ; DOI:10.31254/phyto.2020.9601
Network Pharmacology study on the mechanism of MKA Polyherbal Formulation in combating Respiratory Diseases
1. Department of Biochemistry, Rathnavel Subramaniam College of Arts and Science, Coimbatore- 641402, Tamilnadu, India
2. Principal, Michael Job College of Arts and Science for Women, Coimbatore641103, Tamilnadu, India
*Author to whom correspondence should be addressed.
Received: 30th November, 2020 / Accepted: 18th December, 2020
The Multi-targeted action of Polyherbal formulation is responsible for enhanced therapeutic efficacy in combating various diseases. But, understanding the mode of action of herbal medicine remains a challenge because of its complex metabolomics. Network pharmacology-based approach enables to explore the mechanism of action of polyherbal formulation in biological system. In present investigation, we have explored the molecular mechanism of action of the Polyherbal formulation MKA comprising of three botanicals Mimusops elengi L., Kedrostis foetidissima (Jacq.) Cogn. and Artemisia vulgaris L. in treating respiratory diseases by network pharmacology-based approach. The protein targets were mined from Binding database for the bioactive present in MKA. The disease associated targets were identified using Open target Platform. Based on ligand-target interactions, it was interpreted that MKA could alleviate the symptoms of respiratory disease by multiple mechanisms like EGFR inhibition by Quercetin and Quercetin-3-O-rhamnoside, KDR inhibition by Quercetin, STAT-3 inhibition by ?-sitosterol- ?-Dglucoside, TRPV1 inhibition by phytol acetate, etc. The Protein-protein interaction (PPI) network was constructed using STRING database. KEGG pathway based functional enrichment was also predicted for the PPI network. It was found that multiple ligand-target interactions and protein-protein interactions is responsible for pharmacological activity of MKA in respiratory diseases.
Polyherbal formulation, Respiratory, Ligand, Protein-protein interactions (PPIs), Inhibition.
HOW TO CITE THIS ARTICLE
Poongodi T, Nazeema TH. Network Pharmacology study on the mechanism of MKA Polyherbal Formulation in combating Respiratory Diseases. J Phytopharmacol 2020; 9(6):385-391.
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