The Journal of Phytopharmacology, 2015;4(4):197-201 ; DOI:10.31254/phyto.2015.4401
Effects of Ganoderma lucidum (Curtis) P. Karst and Crinipellis schevczenkovi Buchalo aqueous extracts on skin wound healing
Tetiana A. Krupodorova1 , Victor Yu. Barshteyn2 , Pavlo P. Klymenko3 , Yuri I. Leonov4 , Dmytro W. Shytikov4 , Tetiana N. Orlova4
1. Laboratory of Vegetable Raw Materials Extraction and Bioconversion, Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine, Ukraine, Kyiv, 04123, 2a Osipovskogo st.
2. Laboratory of Vegetable Raw Materials Extraction and Bioconversion, Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine, Ukraine, Kyiv, 04123, 2a Osipovskogo st.
3. Laboratory of Morphology and Cytology, D.F. Chebotarev State Institute of Gerontology National Academy of Medicinal Sciences of Ukraine, Ukraine, Kyiv, 04114, 67 Vyshhorodska st.
4. Laboratory of Pathophysiology and Immunology, D.F. Chebotarev State Institute of Gerontology National Academy of Medicinal Sciences of Ukraine, Ukraine, Kyiv, 04114, 67 Vyshhorodska st.
*Author to whom correspondence should be addressed.
The aqueous extracts of Ganoderma lucidum 1900 (Curtis) P. Karst and Crinipellis schevczenkovi 31 Buchalo mycelia were investigated for skin wound healing activity in vivo using the excision wound healing model. The extracts were prepared by mixing of 100 mg of powdered mycelium of both mushrooms with 1 mL of sterile distilled water for injections. White albino mice line FVB/Cg., 3 months of age (male), were used for the study. The rate of wound healing and the histology of healed wounds in mice have been studied. Visual method of wound study and histological investigation of skin tissue showed the presence of wound healing potential of G. lucidum and C. schevczenkovi mycelia. The wound healing process was expressed more active on 3th day in case of topical application of C. schevczenkovi mycelium extract, but on 5th day the wound healing effects of both mushroom extracts were almost at the same level and statistically better then results in the control group. Wounds treated with mycelial extracts were covered completely on the 6th day compared with 8th day in control group. Wound healing ability of C. schevczenkovi observed in present investigations for the first time.
Skin wound healing, Ganoderma lucidum, Crinipellis schevczenkovi, Mycelium, Aqueous extract.
HOW TO CITE THIS ARTICLE
Krupodorova T A, Klymenko P P, Barshteyn V Y, Leonov Y I, Shytikov D W, Orlova T N. Effects of Ganoderma lucidum (Curtis) P. Karst and Crinipellis schevczenkovi Buchalo aqueous extracts on skin wound healing. The Journal of Phytopharmacology 2015;4(4):197-201.
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