ISSN: 2320-480X
Manuscript Submission

The Journal of Phytopharmacology, 2022;11(2):57-59 DOI:10.31254/phyto.2022.11201

Research Article

Evaluation of acute dermal toxicity of a topical antimastitis gel

Sunil Hajare1 , Ranjit Suresh Ingole1 , Mahesh Kumar2 , Vitthal Ingawale2 , Vivek Borekar3 , David Kumar4 , Bhaskar Ganguly4

1. Post Graduate Institute of Veterinary and Animal Sciences (PGIVAS), Akola - 444104 Maharashtra, India
2. Post Graduate Institute of Veterinary and Animal Sciences (PGIVAS), Akola - 444104, Maharashtra, India
3. Post Graduate Institute of Veterinary and Animal Sciences (PGIVAS), Akola, - 444104 Maharashtra, India
4. Research and Development Unit, Ayurvet Limited, Baddi-173205, Himachal Pradesh, India

*Author to whom correspondence should be addressed.

Received: 3rd February, 2022 / Accepted: 12th March, 2022

Abstract


This study was undertaken to evaluate the acute dermal toxicity of a topical anti-mastitis gel (Mastilep® gel; M/s Ayurvet Limited, India) in accordance with OECD 402 guidelines. Nine adults female Wistar rats, weighing 210-250 g, were used in the study. Following the topical application of the anti-mastitis gel, the animals were observed for the manifestation of toxic effects and mortality. Toxicity was evaluated on the basis of changes in body weight, histological appearances of heart, liver, kidney, and lungs, and blood biochemical parameters viz. AST, ALT, ALP and creatinine. Since no toxic effects or deaths were recorded until completion of the experiment, the anti-mastitis gel was found safe for dermal use.

Keywords


Topical, Anti-mastitis gel, Safety, Acute dermal toxicity, OECD 402, Mastilep® gel.

HOW TO CITE THIS ARTICLE

Hajare S, Ingole RS, Mahesh Kumar, Ingawale V, Borekar V, Kumar D, Ganguly B. Evaluation of acute dermal toxicity of a topical anti-mastitis gel. J Phytopharmacol 2022; 11(2):57-59. doi: 10.31254/phyto.2022.11201

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Copyright

Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.

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