The Journal of Phytopharmacology 2023; 12(1):44-50 DOI:10.31254/phyto.2023.12107

Review Article

Nutraceutical Potential of Vitexin: A Flavone Glycoside

Rajeev Ranjan¹ , Kaushal Kishore² , Rajesh Ranjan³ , Sheikh TJ⁴ , Amit Kumar Jha⁵ , Brijesh Kumar Ojha⁶ , Suman Kumar⁷ , Rinesh Kumar⁷

Rajeev Ranjan,Kaushal Kishore,Rajesh Ranjan,Sheikh TJ,Amit Kumar Jha,Brijesh Kumar Ojha,Suman Kumar,Rinesh Kumar

1. Department of Veterinary Pharmacology and Toxicology, C.V.Sc. & A.H., Rewa (NDVSU), Madhya Pradesh, India
2. Department of Forensic Medicine and Toxicology, S.K.M.C., Muzaffarpur, Bihar, India
3. Department of Veterinary Anatomy & Histology, C.V.Sc. & A. H., Rewa (NDVSU), Madhya Pradesh, India
4. Department of Veterinary Pathology, C.V.Sc. & A.H., Rewa (NDVSU), Madhya Pradesh, India
5. Department of Animal Genetics and Breeding, C.V.Sc. & A.H., Rewa (NDVSU), Madhya Pradesh, India
6. Department of Animal Nutrition C.V.Sc. & A.H., Rewa (NDVSU), Madhya Pradesh, India
7. Department of Veterinary Parasitology, C.V.Sc. & A.H., Jabalpur (NDVSU), Madhya Pradesh, India

*Author to whom correspondence should be addressed.

Received: 26th March, 2022 / Accepted: 20th January, 2023

Abstract

Vitexin is an apigenin flavone glycoside and it is extensively present in numerous edible and medicinalplants. It is considered as important as other flavonoids. It possessed a variety of biological properties,including anti-oxidation, anti-inflammation, anticancer, neuron-protective, cardio-protective, hepatopancreatic protective effects. Other reported health relevant effects, includes fat reduction and glucosemetabolism. The possible mechanism of protective effect through activation or inhibition of the differentsignaling pathways like AMPKa, Nrf-2, mTOR, PUMA, MMP, PARP, JNK, p38, Bcl-2/Bax ratio etc.The molecular targets of vitexin are very critical to utilize its potential effect as emerging chemopreventive and chemotherapeutic agent.